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Use of transgenic mutational test systems in risk assessment of carcinogens
P Schmezer1, C Eckert, U M Liegibel
1Division of Toxicology and Cancer Risk Factors, German Cancer Research Centre, Heidelberg, Germany.
Archives of Toxicology. Supplement. = Archiv Fur Toxikologie. Supplement
|January 27, 1998
Abstract:
Two transgenic in vivo mutation assays are described which are based on LacZ (Muta Mouse) and LacI (Big Blue) shuttle vector systems. Their utility has already been explored by a number of investigators including our laboratory. The evaluation of data derived from these assays confirm that they offer a practical method for studying mutagenic activity and mechanism in a wide range of tissues including those of the respiratory and gastrointestinal tract. Therefore, these transgenic mutation assays are valuable tools to assess the organotropic effects of genotoxic carcinogens.