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Cardiovascular effects of estrogen: implications of the discovery of the estrogen receptor subtype beta
1Department of Surgery, Georgetown University Medical Center, Washington, DC, USA.
Current Opinion in Nephrology and Hypertension
|January 27, 1998
Abstract:
In addition to the traditional estrogen receptor-alpha, a second estrogen receptor was recently discovered, namely estrogen receptor-beta. This review focuses on the cardiovascular significance of the differential ligand activation by these nuclear transcription factors and emphasizes the need for re-evaluation of all previously described estrogen receptor mediated estrogen and antiestrogen effects.