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Vomiting induction by ipecac syrup in dogs and ferrets
M Yamashita1, M Yamashita, J Tanaka
1Department of Emergency Medicine, University of Tsukuba, Japan.
The Journal of Toxicological Sciences
|January 27, 1998
Summary
Ferret and dog models show similar responses to ipecac syrup, with ferrets exhibiting more retching at higher doses. This suggests ferrets are a viable alternative for emesis research.
Area of Science:
- Veterinary Pharmacology
- Animal Models in Research
Background:
- Dogs are commonly used in emesis research.
- Ipecac syrup is a widely studied emetic agent.
Purpose of the Study:
- To evaluate the emetic effects of ipecac syrup in ferrets.
- To compare ferret and dog responses to ipecac syrup for emesis research.
Main Methods:
- Dogs and ferrets were administered varying doses of ipecac syrup (0.1-1.0 ml/kg).
- Control groups received saline.
- Latency, retching, and vomiting were recorded and analyzed.
Main Results:
- Both species showed a dose-dependent increase in vomiting and retching.
- No significant difference in vomiting latency or number was observed between dogs and ferrets.
- Ferrets exhibited a higher number of retching instances than dogs at doses >= 0.25 ml/kg.
Conclusions:
- Ferrets demonstrate comparable efficacy to dogs in emesis research involving ipecac syrup.
- The ferret serves as a suitable and potentially smaller alternative animal model for emesis studies.