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Trace elements and chronic liver diseases

C Loguercio1, V De Girolamo, A Federico

  • 1Cattedra di Gastroenterologia, Seconda Università di Napoli, Italia.

Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)
|January 27, 1998
PubMed
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This study found that liver cirrhosis significantly decreases blood zinc and selenium levels in patients with hepatitis C virus (HCV)-related liver disease. Malnutrition specifically impacts iron levels in these patients.

Area of Science:

  • Hepatology
  • Nutritional Science
  • Trace Element Metabolism

Background:

  • The link between chronic liver disease and trace element (TE) levels remains unclear, with limited data on viral liver diseases, especially concerning malnutrition.
  • Hepatitis C virus (HCV)-related liver disease encompasses various stages, from chronic hepatitis to cirrhosis, potentially impacting nutritional status and TE concentrations.

Purpose of the Study:

  • To investigate blood and plasma trace element levels in patients with HCV-related chronic liver disease.
  • To differentiate the effects of liver disease severity and malnutrition on trace element status.

Main Methods:

  • Analysis of blood and plasma trace element concentrations (including Zn, Se, Fe) in patients with chronic hepatitis (n=8) and liver cirrhosis (n=32).
  • Comparison of TE levels between patients with and without malnutrition.

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  • Inclusion of a healthy volunteer control group (n=10).

    • Main Results:

    • Cirrhotic patients exhibited significantly lower blood zinc (Zn) and selenium (Se) levels, irrespective of nutritional status.
    • Plasma iron (Fe) levels were significantly reduced only in cirrhotic patients who were also malnourished.
    • Liver impairment was identified as the primary cause for decreased Se and Zn levels in non-alcoholic liver disease.

    Conclusions:

    • Liver disease severity, particularly cirrhosis, is the main driver for reduced blood Zn and Se levels in HCV patients.
    • Malnutrition exacerbates TE deficiencies, specifically affecting iron levels in cirrhotic individuals.
    • These findings highlight the distinct roles of liver function and nutritional status in trace element dysregulation.