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Treatment of retinoblastoma vitreous base seeding
S A Madreperla1, J L Hungerford, D Doughty
1Department of Ocular Oncology, St. Bartholomew's Hospital, London, England.
Objective:
The purpose of the study is to describe results of a new treatment for retinoblastoma vitreous base seeding.
Design:
The study design was a retrospective review of patients treated at an ocular oncology referral center.
Participants:
Five eyes of five patients with vitreous base seeding that occurred after previous external beam radiation therapy were treated between October 1987 and December 1994.
Intervention:
A customized plaque made from iridium-192/platinum wire was placed to deliver 4000 cGy to the tumor apex along its entire length and systemic chemotherapy (consisting of carboplatin, vincristine, and etoposide) was given.
Main Outcome Measures:
Eye preservation and tumor control were measured.
Results:
Vitreous base seeding was controlled completely and the eye preserved in four of the five treated eyes with an average follow-up of 26.2 months.
Conclusions:
The combination of a customized iridium-192 plaque and systemic chemotherapy is an effective means of treating vitreous base seeding of retinoblastoma.