Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Formation and function of Spemann's organizer

R Harland1, J Gerhart

  • 1Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA. harland@mendel.berkeley.edu

Annual Review of Cell and Developmental Biology
|January 1, 1997
PubMed
Summary

The amphibian embryo

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of altering ruminal pH by dietary buffer supplementation on methane emissions from sheep fed forage rape.

Animal : an international journal of animal bioscience·2019
Same author

Sheep from low-methane-yield selection lines created on alfalfa pellets also have lower methane yield under pastoral farming conditions.

Journal of animal science·2017
Same author

A rare cause of small bowel infarction.

Journal of surgical case reports·2014
Same author

Heritability estimates of methane emissions from sheep.

Animal : an international journal of animal bioscience·2013
Same author

Case report: a case of subclavius posticus muscle mimicking a mass on mammogram.

Clinical radiology·2009
Same author

A study of psychiatrists' concepts of mental illness.

Psychological medicine·2008

Area of Science:

  • Developmental biology
  • Embryogenesis
  • Cell signaling pathways

Background:

  • Early amphibian development involves the formation of key signaling centers.
  • Maternal factors localized during oogenesis play a crucial role in initiating developmental pathways.
  • The interplay between general mesoendoderm inducers and dorsal modifiers establishes embryonic axes.

Purpose of the Study:

  • To elucidate the molecular mechanisms and cellular origins of the amphibian organizer.
  • To understand how maternal signals specify the Nieuwkoop center and subsequently the organizer.
  • To investigate the role of the organizer in pattern formation and morphogenesis during gastrulation.

Main Methods:

  • Analysis of maternal agent distribution and signaling pathways (TGF-beta, Wnt).
  • Identification of the Nieuwkoop center as the source of key maternal signals.
  • Investigation of zygotic gene expression and protein secretion by the organizer.

Main Results:

  • The organizer arises from cells responding to both mesoendoderm-inducing and dorsal-modifying maternal signals.
  • The Nieuwkoop center, secreting these signals, specifies the organizer's location.
  • The organizer secretes antagonists to BMP and Wnt ligands, promoting dorsal development and pattern formation.

Conclusions:

  • The organizer's formation is a precise process driven by maternally inherited factors.
  • The organizer acts as a crucial signaling center, orchestrating gastrulation and axis formation.
  • Organizer-secreted factors pattern the embryo by antagonizing ventralizing signals.

Related Experiment Videos