Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Transposable element-host interactions: regulation of insertion and excision

M Labrador1, V G Corces

  • 1Department of Biology, Johns Hopkins University, Baltimore, Maryland 21218, USA.

Annual Review of Genetics
|January 1, 1997
PubMed
Summary

Transposable elements (TEs) can harm hosts but are regulated by host genomes, especially retrotransposons. This regulation fosters a symbiotic relationship, with TEs sometimes benefiting their hosts.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The International Guideline for the Definition, Classification, Diagnosis and Management of Urticaria.

Allergy·2026
Same author

A Specialized Therapeutic Approach to Chronic Urticaria Refractory to H1-Antihistamines Improves Disease Burden: The Spanish AWARE Experience.

Journal of investigational allergology & clinical immunology·2020
Same author

Advertising Games of Chance in Adolescents and Young Adults in Spain.

Journal of gambling studies·2020
Same author

Component-Resolved Diagnosis of Dog Allergy.

Journal of investigational allergology & clinical immunology·2017
Same author

Relevance of Allergenic Sensitization to Cynodon dactylon and Phragmites communis: Cross-reactivity With Pooideae Grasses.

Journal of investigational allergology & clinical immunology·2016
Same author

Assessment of severity and quality of life in chronic urticaria.

Journal of investigational allergology & clinical immunology·2014

Area of Science:

  • Genetics
  • Molecular Biology
  • Evolutionary Biology

Background:

  • Transposable elements (TEs) are mobile genetic sequences that propagate by inserting into new genomic locations.
  • TE transposition can negatively impact host fitness, necessitating regulatory mechanisms.
  • TE regulation varies based on their structure: DNA elements rely on intrinsic transposase, while retrotransposons are controlled by host genomes.

Purpose of the Study:

  • To explore the regulatory mechanisms governing transposable element mobilization.
  • To understand the interplay between host genomes and transposable elements.
  • To highlight the emerging role of transposons in host well-being.

Main Methods:

  • Comparative genomics analysis of TE structures and regulatory elements.

Related Experiment Videos

  • Molecular assays to investigate TE expression and insertion patterns.
  • Bioinformatic approaches to analyze host-TE interactions.

    • Main Results:

    • DNA transposons are primarily regulated by intrinsic factors.
    • Retrotransposon mobilization is controlled by the host at multiple levels, including expression and insertional specificity.
    • Evidence suggests a co-evolutionary, symbiotic relationship between TEs and hosts.

    Conclusions:

    • Host genomes exert significant control over transposable element activity, particularly retrotransposons.
    • This control facilitates a symbiotic relationship, where TEs can provide benefits to the host organism.
    • Transposable elements are not solely parasitic and can contribute to host evolution and adaptation.