Is vestibular micropapillomatosis associated with human papillomavirus infection?

The aetiology and clinical significance of vulvar papillomatosis is still controversial. To verify the association of micropapillomatosis labialis with certain types of HPV-related lower genital tract infections, 25 patients with colposcopic aspects of vulvar papillomatosis were recruited and vulvar biopsies were obtained for histologic examination and in situ hybridization. Sixteen patients with vulvodynia, without any pathologic vulvar aspects, served as a control group. Histologic evidence of HPV was found in 20 cases (80%) of vulvar papillomatosis while only one (4%) of the study patients was positive for HPV-DNA. These results seem to confirm the scarse correlation between vestibular papillomatosis and HPV. In our opinion physicians must be cautions when treating these lesions even in cases with positive histologic results. Colposcopy is, therefore, of fundamental importance for an accurate diagnosis of vestibular papillomatosis and successful management.