Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Age-associated changes in Ca(2+)-dependent processes: relation to hippocampal synaptic plasticity

T C Foster1, C M Norris

  • 1Department of Psychology, University of Virginia, Charlottesville 22903, USA. TCF5A@Virginia.EDU

Hippocampus
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Accelerated Epigenetic Aging Mediates the Association between Vitamin D Levels and Knee Pain in Community-Dwelling Individuals.

The journal of nutrition, health & aging·2022
Same author

Astrocyte mitochondria: Central players and potential therapeutic targets for neurodegenerative diseases and injury.

Ageing research reviews·2020
Same author

Expression of a Constitutively Active Human Insulin Receptor in Hippocampal Neurons Does Not Alter VGCC Currents.

Neurochemical research·2018
Same author

Central role for NMDA receptors in redox mediated impairment of synaptic function during aging and Alzheimer's disease.

Behavioural brain research·2016
Same author

The varying effects of obesity and morbid obesity on outcomes following cardiac transplantation.

International journal of obesity (2005)·2016
Same author

FK506-binding protein 1b/12.6: a key to aging-related hippocampal Ca2+ dysregulation?

European journal of pharmacology·2013

Aging impairs memory by disrupting calcium (Ca2+) regulation, affecting brain plasticity. This review explores how altered Ca2+ homeostasis in aging brains may lead to synaptic depression and memory loss.

Area of Science:

  • Neuroscience
  • Aging Research
  • Calcium Signaling

Background:

  • Altered calcium (Ca2+) homeostasis is implicated in aging and neuropathology, particularly memory deficits.
  • Hippocampal synaptic plasticity, crucial for memory, is dependent on Ca2+.
  • This suggests a link between impaired Ca2+ regulation and age-related memory decline.

Purpose of the Study:

  • To review evidence for Ca2+ dysregulation during aging.
  • To explore the interaction between aging-related Ca2+ changes and Ca2+-dependent synaptic plasticity.
  • To propose mechanisms linking Ca2+ dysregulation to age-associated memory deficits.

Main Methods:

  • Literature review of studies on calcium homeostasis and aging.
  • Analysis of research on Ca2+-dependent synaptic plasticity in aging models.

Related Experiment Videos

  • Synthesis of evidence linking Ca2+ dysregulation to synaptic modifications.

    • Main Results:

    • Evidence suggests significant Ca2+ dysregulation occurs during the aging process.
    • Aging-induced changes in Ca2+ handling can impact synaptic plasticity mechanisms.
    • Altered Ca2+ regulation may shift synaptic modification thresholds towards depression.

    Conclusions:

    • Ca2+ dysregulation is a key factor in age-related memory deficits.
    • Changes in Ca2+ homeostasis interact with synaptic plasticity, potentially impairing memory formation.
    • The aging brain may exhibit a predisposition towards synaptic depression due to altered Ca2+ regulation.