Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hepatitis C virus genotypes implicated in mixed cryoglobulinemia

Q T Nguyen1, M Leruez-Ville, F Ferrière

  • 1Laboratoire de Bactériologie-Virologie, Hôpital Avicenne, Bobigny, France.

Journal of Medical Virology
|January 27, 1998
PubMed
Summary

Hepatitis C virus (HCV) infection may cause mixed cryoglobulinemia. This study found HCV genotypes 1 and 2 more common in patients with symptomatic cryoglobulinemia, recommending HCV genotyping for diagnosis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

COVID-19 and chronic liver disease: results from the 1219 patients French registry.

Scientific reports·2025
Same author

BSR and BHPR guidelines for the management of adults with ANCA associated vasculitis.

Rheumatology (Oxford, England)·2007
Same author

[Indications for immunoglobulins. Recommendations of CEDIT of AP-HP in 2006].

La Revue de medecine interne·2007
Same author

EULAR evidence-based recommendations on the management of systemic glucocorticoid therapy in rheumatic diseases.

Annals of the rheumatic diseases·2007
Same author

Mortality and risk factors of scleroderma renal crisis: a French retrospective study of 50 patients.

Annals of the rheumatic diseases·2007
Same author

Development and validation of a scale for mouth handicap in systemic sclerosis: the Mouth Handicap in Systemic Sclerosis scale.

Annals of the rheumatic diseases·2007

Area of Science:

  • Virology
  • Immunology
  • Hepatology

Background:

  • Hepatitis C virus (HCV) is increasingly linked to mixed cryoglobulinemia.
  • Understanding the role of specific HCV genotypes in disease pathogenesis is crucial.

Purpose of the Study:

  • To investigate the association between hepatitis C virus genotypes and the development of symptomatic mixed cryoglobulinemia.
  • To determine if HCV genotyping can aid in identifying patients at risk for cryoglobulinemia.

Main Methods:

  • HCV genotyping was performed on 45 infected patients using direct sequencing of 5' non-coding region PCR products.
  • Patient samples were analyzed for the presence and type of HCV infection.

Main Results:

  • HCV genotypes 1 and 2 were significantly more prevalent in patients presenting with symptomatic mixed cryoglobulinemia.

Related Experiment Videos

  • Genotypes 4 and 5 were also identified in a subset of French patients (9.3%).

    • Conclusions:

    • HCV genotype appears to be a significant factor in the onset of mixed cryoglobulinemia.
    • HCV genotyping by sequence determination is a recommended diagnostic approach for patients with suspected cryoglobulinemia.