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Small bowel and fecal microbiology in children suffering from persistent diarrhea in Bangladesh

P K Bardhan1, M J Albert, N H Alam

  • 1International Cenre for Diarrhoeal Disease Research, Bangladesh Dhaka.

Journal of Pediatric Gastroenterology and Nutrition
|January 27, 1998
PubMed

Insights

Enteroaggregative Escherichia coli (E. coli) were significantly associated with persistent diarrhea in Bangladeshi children. This finding suggests targeted therapies against this pathogen may help manage persistent diarrhea cases.

Area of Science:

  • Microbiology
  • Pediatric Gastroenterology
  • Infectious Diseases

Background:

  • Persistent diarrhea in children has complex causes.
  • Understanding the microbial role is crucial for effective treatment.
  • This study investigated microorganisms in persistent diarrhea in Bangladesh.

Purpose of the Study:

  • To identify the role of microorganisms in the etiology and pathogenesis of persistent diarrhea.
  • To compare microbial flora in children with persistent diarrhea, acute diarrhea, and healthy controls.

Main Methods:

  • Analyzed duodenal aspirates and stool samples from children with persistent diarrhea, acute diarrhea, and healthy controls.
  • Quantified total aerobic microflora and identified enteric pathogens.
  • Compared microbial profiles between study groups.

Main Results:

  • Children with persistent diarrhea showed a greater variety of duodenal flora compared to controls.
  • Gram-negative rods predominated in persistent diarrhea, unlike Gram-positive cocci in controls.
  • Enteroaggregative Escherichia coli (E. coli) were significantly associated with persistent diarrhea, along with Aeromonas spp. and Klebsiella spp.

Conclusions:

  • Confirmed an association between enteroaggregative E. coli and persistent diarrhea.
  • Suggests evaluating therapies targeting enteroaggregative E. coli for managing persistent diarrhea.
Abstract

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