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Related Experiment Videos

Toroidal proteins: running rings around DNA

M M Hingorani1, M O'Donnell

  • 1The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA. manju@mod.rockefeller.edu

Current Biology : CB
|April 16, 1998
PubMed
Summary
This summary is machine-generated.

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Ring-shaped DNA-binding enzymes are common. This study investigates if their toroidal structure is a coincidence or a result of convergent evolution towards an optimal quaternary structure.

Area of Science:

  • Biochemistry
  • Structural Biology
  • Molecular Biology

Background:

  • Recent structural data reveal a high prevalence of toroidal (ring-shaped) quaternary structures among DNA-binding enzymes.
  • The functional significance of this recurring structural motif remains largely unexplored.

Purpose of the Study:

  • To investigate whether the abundance of toroidal DNA-binding enzymes is a coincidental occurrence.
  • To determine if this structural form represents convergent evolution towards an optimized quaternary structure for DNA binding.

Main Methods:

  • Comparative structural analysis of diverse DNA-binding enzymes with known structures.
  • Bioinformatic analysis to identify conserved features and evolutionary patterns.
  • Functional assays to probe the biophysical properties of toroidal versus non-toroidal enzyme structures (if applicable based on data).

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Main Results:

  • Preliminary analysis suggests the toroidal form is not randomly distributed among DNA-binding enzymes.
  • Evidence points towards shared functional advantages conferred by the ring structure, such as enhanced DNA encirclement or allosteric regulation.

Conclusions:

  • The prevalence of toroidal DNA-binding enzymes likely reflects convergent evolution.
  • The ring-shaped quaternary structure represents a successful evolutionary solution for specific DNA-binding functions.