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Related Experiment Videos

Radical pancreatectomy

H A Reber1, B Gloor

  • 1Section of Gastrointestinal Surgery, University of California-Los Angeles, Los Angeles, California 90095-6904, USA.

Surgical Oncology Clinics of North America
|March 7, 1998
PubMed
Summary
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Modified Whipple procedures involving wider dissections and vein resection are safe but lack evidence of improved cure rates for pancreatic cancer. Further research is needed to validate oncologic benefits.

Area of Science:

  • Surgical Oncology
  • Gastrointestinal Surgery

Background:

  • The standard pancreaticoduodenectomy (Whipple procedure) is a cornerstone treatment for pancreatic cancer.
  • Efforts to improve cure rates have led to modifications of the standard procedure.

Purpose of the Study:

  • To describe a modified pancreaticoduodenectomy.
  • To critically review the results of this modified procedure.

Main Methods:

  • The modified operation includes wider soft tissue and lymph node dissection.
  • Resection of a segment of the superior mesenteric and portal veins is incorporated.

Main Results:

  • The modified procedure can be performed safely.
  • There is little additional morbidity compared to the standard resection.

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  • No objective evidence currently supports an increased cure rate.

    • Conclusions:

    • While technically feasible and safe, the modified Whipple procedure does not demonstrate improved oncologic outcomes.
    • Further investigation is required to determine if this extensive resection offers a survival advantage.