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Gender-related considerations in clinical pharmacology and drug therapeutics
C X Xie1, L T Piecoro, D P Wermeling
1Center for Pharmaceutical Science and Technology, College of Pharmacy, University of Kentucky, Lexington, USA.
Abstract:
The pharmacokinetics and pharmacodynamics in women are different from that in men because of women's unique anatomy and physiology. Recently, gender-related studies in clinical pharmacology have been emerging, supporting the observation of gender-induced variations in drug response. The hormonal fluctuations during a woman's life span may influence pharmacotherapy. Therefore, gender-related pharmacology should be taken into consideration when prescribing medication for a woman. Data from drug developmental studies, FDA approved label directions, and other clinical research evaluation women's responses to medications are necessary to make optimal pharmacotherapeutic decisions.
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