Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Inflammatory mechanisms in chronic sinusitis

C Bachert1, P B Van Cauwenberge

  • 1Kliniekhoofd, NKO-Dep., UZ Gent, Belgium.

Acta Oto-Rhino-Laryngologica Belgica
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Real-world effectiveness of omalizumab in patients with chronic rhinosinusitis with nasal polyps (CRSwNP): findings from CHRINOSOR.

Rhinology·2026
Same author

Indication for biologics in a real-world cohort of dupilumab treated chronic rhinosinusitis with nasal polyps patients according to international recommendations: evidence from the European CRS Outcome Registry (CHRINOSOR).

Rhinology·2025
Same author

The alphaherpesvirus gE/gI glycoprotein complex and proteases jointly orchestrate invasion across the host's upper respiratory epithelial barrier.

mBio·2024
Same author

The impact of mepolizumab on sleep impairment in CRSwNP: post hoc analyses of SYNAPSE and MUSCA.

Rhinology·2024
Same author

Mepolizumab in CRSwNP/ECRS and NP: the phase III randomised MERIT trial in Japan, China, and Russia.

Rhinology·2024
Same author

The relationship of sinus opacification, olfaction and dupilumab efficacy in patients with CRSwNP.

Rhinology·2023

Interleukin-5 (IL-5) protein is key in nasal polyposis inflammation, driving tissue eosinophilia. Understanding cytokine patterns aids in classifying chronic sinusitis and improving treatment outcomes.

Area of Science:

  • Immunology
  • Otolaryngology
  • Molecular Biology

Background:

  • Chronic sinusitis and nasal polyposis involve complex inflammatory processes.
  • Cytokines, chemokines, and adhesion molecules are crucial in understanding sinus disease pathogenesis.
  • Previous research highlighted roles of interleukin (IL)-1 beta, IL-6, and IL-8 in acute sinusitis.

Purpose of the Study:

  • To investigate the role of cytokine patterns in the pathomechanisms of chronic sinusitis and nasal polyposis.
  • To identify key inflammatory mediators differentiating sinusitis subgroups.
  • To explore the link between specific cytokines and tissue eosinophilia in nasal polyposis.

Main Methods:

  • Analysis of cytokine and chemokine profiles in patients with acute and chronic sinus diseases.

Related Experiment Videos

  • Comparison of cytokine expression in nasal polyposis tissues versus controls and antrochoanal polyps.
  • Quantification of specific proteins like IL-3 and IL-5.

    • Main Results:

    • Interleukin-3 (IL-3) protein dominates the cytokine profile in chronic sinusitis.
    • Significantly increased synthesis of Interleukin-5 (IL-5) protein was observed in bilateral nasal polyposis.
    • IL-5 was notably absent in control subjects and antrochoanal polyps.

    Conclusions:

    • IL-5 is identified as a critical protein in the pathogenesis of tissue eosinophilia within nasal polyposis.
    • Cytokine profiling offers a potential tool for differentiating between sinusitis subtypes.
    • Further understanding of inflammatory pathways can guide targeted therapeutic strategies for chronic sinus diseases.