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Correlation between human platelet cytoplasmic membrane outer leaflet fluidity, Na+/H+ exchanger activity and aging

C F Marinho¹, J Costa-Maia, J Pinto-de-Barros

¹Center for Neuroscience of Coimbra, School of Medicine, University of Coimbra, Portugal.

European Archives of Psychiatry and Clinical Neuroscience

|January 1, 1997

Summary

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Aging reduces platelet membrane fluidity, impacting brain aging. This study found membrane order increases with age, but Na+/H+ antiporter activity remains unchanged, suggesting fluidity is key to brain health.

Area of Science:

Gerontology
Biochemistry
Cell Biology

Background:

Platelet cytoplasmic membranes serve as models for neuronal membranes.
Aging affects cellular structures and functions, potentially influencing brain pathology.
The Na+/H+ antiporter plays a role in cellular homeostasis.

Purpose of the Study:

To examine how aging affects platelet membrane fluidity and Na+/H+ antiporter activity.
To determine the influence of membrane order and age on the Na+/H+ exchanger.
To explore the role of these factors in normal brain aging.

Main Methods:

Cross-sectional survey of 19 healthy subjects (age 22-83).
Analysis of washed platelets as neuronal models.
Statistical analysis including correlation and Sewall-Wright path coefficient analysis.

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Main Results:

A significant positive correlation between age and membrane structural order was observed.
Age had minimal influence on Na+/H+ exchanger activity.
Cytoplasmic membrane outer leaflet fluidity and mean platelet volume strongly influenced Na+/H+ exchanger activity.

Conclusions:

Decreased membrane outer leaflet fluidity is associated with aging.
Na+/H+ antiporter activity appears unchanged in normal aging.
Reduced membrane fluidity may contribute to normal brain aging processes.