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[Fever of unknown origin in internal medicine. The experience of Spanish authors over 20 years]

J M Ramos Rincón1, R Ramos Guevara, F Herrero Huerta

  • 1Servicio de Medicina Interna, Hospital General Universitario Morales Meseguer, Murcia.

Anales De Medicina Interna (Madrid, Spain : 1984)
|January 31, 1998
PubMed

Insights

The causes of fever of unknown origin (FUO) have shifted over 25 years. Infections remain common, but neoplastic and collagen vascular diseases are increasingly identified as key etiologies.

Area of Science:

  • Internal Medicine
  • Clinical Epidemiology

Context:

  • Fever of unknown origin (FUO) presents diagnostic challenges.
  • Etiologic spectrum of FUO has evolved over time.
  • Understanding these shifts is crucial for effective diagnosis.

Purpose:

  • To analyze the etiologic spectrum of FUO.
  • To evaluate diagnostic approaches for FUO.
  • To assess changes in FUO causes over a 25-year period (1970-1995).

Summary:

  • A review of 14 Internal Medicine articles encompassing 914 FUO cases from 1970-1995.
  • Infections were the leading cause (41.2%), notably tuberculosis, brucellosis, and abscesses.
  • Neoplasms (19.2%) and collagen vascular diseases (13.7%) were also significant, with lymphoma and systemic lupus erythematosus being prominent.

Impact:

  • Improved diagnostic procedures have altered the FUO landscape.
  • A decrease in infectious causes like brucellosis is observed.
  • An increase in neoplastic and collagen vascular diseases (excluding lupus) as FUO etiologies is evident.

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