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[Acute hepatitis following amiodarone administration]

E Tagliamonte1, G Cice, V Ducceschi

  • 1Cattedra di Cardiologia, II Università degli Studi, Napoli.

Minerva Cardioangiologica
|January 31, 1998
PubMed
Summary

A 61-year-old man experienced acute hepatitis following intravenous amiodarone. While amiodarone can cause liver issues, the solvent polysorbate 80 may be the primary culprit.

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Area of Science:

  • Cardiology
  • Hepatology
  • Clinical Pharmacology

Background:

  • Amiodarone is a widely used antiarrhythmic medication for supraventricular arrhythmias.
  • Long-term amiodarone therapy, especially at high doses, is associated with potential hepatotoxicity.
  • Intravenous formulations of amiodarone require careful consideration for adverse effects.

Observation:

  • A patient on chronic amiodarone therapy developed acute hepatitis after intravenous administration.
  • Laboratory tests revealed abnormal kidney and liver function.
  • The patient was asymptomatic for drug-induced liver injury.

Findings:

  • Hepatotoxicity was suspected following intravenous amiodarone.
  • Liver and kidney function normalized within 20 days of drug discontinuation.

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  • Polysorbate 80, an excipient in the intravenous formulation, was identified as a potential cause of acute hepatic disease.

    • Implications:

    • This case highlights the potential for acute liver injury from intravenous amiodarone.
    • Polysorbate 80 should be considered as a potential etiological agent in amiodarone-induced hepatotoxicity.
    • Further investigation into the role of excipients in drug-induced organ damage is warranted.