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[Striato-pallido-dentate calcifications]

M V Baptista1, J Vale, O Leitão

  • 1Serviço de Neurologia, Hospital Egas Moniz, Lisboa.

Acta Medica Portuguesa
|August 1, 1997
PubMed
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Striato-pallido-dentate calcifications (SPDC) involve calcium deposits in the brain. This study found associations with parathyroid disorders and neurological symptoms like epilepsy, dementia, and parkinsonism.

Area of Science:

  • Neurology
  • Radiology
  • Metabolic Disorders

Background:

  • Striato-pallido-dentate calcifications (SPDC) are characterized by calcium deposits in specific brain regions.
  • Metabolic derangements, especially parathyroid disorders, are frequently linked to SPDC.
  • Fahr's syndrome is traditionally reserved for idiopathic cases of such calcifications.

Purpose of the Study:

  • To investigate the clinical and laboratory features of patients with SPDC.
  • To explore the association between SPDC and metabolic disorders, particularly hypocalcemia.
  • To differentiate SPDC from other calcification entities and discuss basal ganglia mineralization pathophysiology.

Main Methods:

  • Retrospective analysis of seven patients diagnosed with SPDC.

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  • Clinical evaluation of neurological manifestations.
  • Laboratory testing for metabolic derangements, including calcium levels and parathyroid function.
  • Main Results:

    • Three out of seven patients presented with hypocalcemia, including two with pseudohypoparathyroidism and one with hypoparathyroidism.
    • Fahr's syndrome was diagnosed in four patients.
    • Reported neurological manifestations included epilepsy, dementia, and parkinsonism.

    Conclusions:

    • SPDC is associated with various metabolic disorders, notably parathyroid dysfunction.
    • Distinguishing SPDC from other basal ganglia calcifications is crucial for accurate diagnosis and management.
    • Further research into the pathophysiology of basal ganglia mineralization is warranted.