Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

MARs mission update

W R Walter1, G B Singh, S A Krawetz

  • 1Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan 48201, USA.

Biochemical and Biophysical Research Communications
|February 3, 1998
PubMed
Summary

Nuclear matrix association regions (MARs) are key to gene organization. This study reveals conserved MAR sequences in the beta-globin locus, suggesting their critical role in regulating hematopoietic genes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Community health volunteer for blood pressure control in rural people with stroke in India: Pilot randomised trial.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2023
Same author

Phthalates impact on the epigenetic factors contributed specifically by the father at fertilization.

Epigenetics & chromatin·2023
Same author

Radiological evaluation of lacrimal apparatus injury after functional endoscopic sinus surgery.

The Journal of laryngology and otology·2021
Same author

A rare case of extra-nasopharyngeal angiofibroma of the septum in a female child.

The Journal of laryngology and otology·2017
Same author

Sterilization of Hypodermic Syringe.

The Indian medical gazette·2017
Same author

Role of circumferential subannular tympanoplasty in anterior and subtotal perforations.

The Journal of laryngology and otology·2017

Area of Science:

  • Genomics
  • Molecular Biology
  • Gene Regulation

Background:

  • Genes are organized into chromatin domains and anchored to the nuclear matrix via MARs.
  • The precise mechanisms governing beta-globin locus gene expression are not fully understood.

Purpose of the Study:

  • To investigate the role of MAR sequences in the regulation of the beta-globin locus.
  • To explore the conservation and genomic distribution of MARs associated with hematopoietic genes.

Main Methods:

  • Comparative genomic analysis of MAR sequences.
  • Examination of MAR distribution within the beta-globin gene cluster.

Main Results:

  • Specific MAR sequences within the beta-globin locus are conserved across the genome.
  • These conserved MARs are associated with other hematopoietic lineage genes.
  • High density and shared nature of MARs within the beta-globin locus were observed.

Conclusions:

  • Conserved MAR sequences play a significant role in the beta-globin locus.
  • MARs likely function as critical gene regulatory elements for hematopoietic genes.

Related Experiment Videos