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Related Experiment Videos

Aging, memory, and mild cognitive impairment

R C Petersen1, G E Smith, S C Waring

  • 1Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA.

International Psychogeriatrics
|January 1, 1997
PubMed
Summary

Patients with mild cognitive impairment (MCI) who have the apolipoprotein E epsilon 4 allele are more likely to develop Alzheimer's disease (AD). Early diagnosis and monitoring of MCI patients can predict AD progression.

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Area of Science:

  • Neurology
  • Geriatrics
  • Neuroscience

Background:

  • High-risk patients for Alzheimer's disease (AD) are a key research focus.
  • Mild cognitive impairment (MCI) is a clinical entity suitable for therapeutic interventions.
  • Mayo Clinic reports 5-year experience characterizing MCI patients.

Purpose of the Study:

  • To characterize mild cognitive impairment (MCI) patients.
  • To identify predictors of progression from MCI to Alzheimer's disease (AD).
  • To evaluate the utility of MCI patients in therapeutic intervention studies.

Main Methods:

  • Recruited community-dwelling individuals receiving general medical care.
  • Diagnosed MCI based on memory complaints, normal daily living/cognition, abnormal memory for age, and absence of dementia.

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  • Followed over 75 MCI patients longitudinally for up to 5 years.
  • Evaluated cognitive profiles and apolipoprotein E (APOE) status.

    • Main Results:

    • Approximately 10-15% of MCI subjects progressed to AD annually.
    • Certain learning and memory features predicted progression.
    • Apolipoprotein E (APOE) epsilon 4 allele was the strongest predictor of rapid conversion to AD.

    Conclusions:

    • Diagnostic criteria for MCI patients likely to convert to AD can be defined.
    • The natural history of MCI is becoming clearer.
    • MCI patients are a crucial group for studying therapeutic interventions for AD.