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Updated: Aug 14, 2026

Identification and Characterization of Metastatic Factors by Gene Transfer into the Novel RIP-Tag; RIP-tva Murine Model
Published on: October 16, 2017
Sheep pulmonary adenomatosis: a unique model of retrovirus-associated lung cancer
M Palmarini1, H Fan, J M Sharp
1Cancer Research Institute, University of California Irvine 92697, USA. massimo@darwin.bio.uci.edu
Abstract:
Sheep pulmonary adenomatosis (SPA) is a contagious bronchiolo-alveolar carcinoma of sheep associated with an exogenous type D/B retrovirus known as jaagsiekte sheep retrovirus (JSRV). SPA represents a unique model for lung cancer, and studies on its aetiopathogenesis can provide further insight into the mechanisms of epithelial neoplasms.
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