Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Toxic interactions between disopyramide and propranolol in chick embryos

Y Yoshiyama1, T Sugiyama, H Miyazaki

  • 1Division of Clinical Pharmacy, Kyoritsu College of Pharmacy, Tokyo, Japan.

Biological & Pharmaceutical Bulletin
|February 3, 1998
PubMed
Summary

The combined use of disopyramide and propranolol significantly slows heart rate and causes arrhythmia in chick embryos. This drug interaction warrants further investigation for potential cardiovascular risks.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Soluble complement receptor type 1 inhibited the systemic organ injury caused by acid instillation into a lung.

Anesthesiology·1996
Same author

Functional analysis of the cytoplasmic domain of the human Mpl receptor for tyrosine-phosphorylation of the signaling molecules, proliferation and differentiation.

FEBS letters·1996
Same author

The biologic properties of recombinant human thrombopoietin in the proliferation and megakaryocytic differentiation of acute myeloblastic leukemia cells.

Blood·1996
Same author

NO donors stimulate noradrenaline release from rat hippocampus in a calmodulin-dependent manner in the presence of L-cysteine.

Journal of cellular physiology·1996
Same author

Intermolecular interactions of antimicrobial fluoroquinolones with purified rat liver CYP1A2 studied by proton nuclear magnetic resonance spectroscopy.

Xenobiotica; the fate of foreign compounds in biological systems·1996
Same author

Effect of recombinant human thrombopoietin in nonhuman primates with chemotherapy-induced thrombocytopenia.

British journal of haematology·1996

Area of Science:

  • Pharmacology
  • Cardiovascular Toxicology
  • Developmental Toxicology

Background:

  • Disopyramide and propranolol are commonly prescribed cardiovascular medications.
  • Understanding drug interactions is crucial for patient safety, especially during development.

Purpose of the Study:

  • To investigate the toxic interaction between disopyramide and propranolol.
  • To assess the effects of this drug combination on heart rate and rhythm in a developing organism.

Main Methods:

  • Fertilized White Leghorn chick eggs were incubated and treated on day 16.
  • Disopyramide, with and without propranolol, was injected into the air sac.
  • Electrocardiograms (ECGs) were recorded for 60 minutes post-injection.

Related Experiment Videos

Main Results:

  • Neither drug alone significantly altered heart rate compared to controls.
  • The combination of disopyramide and propranolol significantly decreased heart rate.
  • Disopyramide alone and in combination with propranolol induced cardiac arrhythmia.

Conclusions:

  • The interaction between disopyramide and propranolol significantly impacts embryonic cardiovascular function.
  • This combination can lead to bradycardia and arrhythmia in developing chick embryos.
  • Further research is needed to elucidate the mechanisms and clinical implications of this interaction.