Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Multiple pancreatic masses associated with autoimmunity

M Ohana1, K Okazaki, K Hajiro

  • 1Department of Gastroenterology, Tenri Hospital, Nara, Japan.

The American Journal of Gastroenterology
|February 3, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pseudotumorous pancreatitis associated with ulcerative colitis.

Internal medicine (Tokyo, Japan)·2002
Same author

Liver abscess caused by Clostridium difficile.

Scandinavian journal of infectious diseases·2001
Same author

Endophthalmitis with brain, lung, and liver abscesses associated with an occult colon cancer.

The American journal of gastroenterology·2001
Same author

Diffuse intrahepatic recurrence after resection of hepatocellular carcinoma.

Hepato-gastroenterology·2000
Same author

Clinical analysis of autoimmune-related pancreatitis.

The American journal of gastroenterology·2000
Same author

Endoscopic removal of colonic neurinoma arising from the submucosa.

The American journal of gastroenterology·2000
Same journal

Calendar of Courses, Symposiums and Conferences.

The American journal of gastroenterology·2026
Same journal

Molecular Nonendoscopic Tests for the Early Detection of Esophageal Squamous Carcinoma and High-Grade Dysplasia: Promising Progress.

The American journal of gastroenterology·2026
Same journal

ACG Clinical Guideline: Colonic Diverticulitis.

The American journal of gastroenterology·2026
Same journal

Continuing Medical Education Questions: July 2026.

The American journal of gastroenterology·2026
Same journal

Continuing Medical Education Questions: July 2026.

The American journal of gastroenterology·2026
Same journal

2026 CME Information.

The American journal of gastroenterology·2026
See all related articles

Autoimmune pancreatitis can manifest as multiple pancreatic masses, particularly in patients with Sjögren's syndrome. Treatment with oral prednisolone led to significant improvement in this case.

Area of Science:

  • Immunology
  • Gastroenterology
  • Pathology

Background:

  • Sjögren's syndrome is an autoimmune disorder primarily affecting exocrine glands.
  • Autoimmune pancreatitis (AIP) is a distinct clinicopathological entity.
  • Pancreatic involvement in Sjögren's syndrome is uncommon but recognized.

Observation:

  • A 59-year-old woman presented with high serum gamma-globulin, positive antinuclear antibody, and multiple pancreatic masses.
  • Over one year, Sjögren's syndrome developed, with pancreatic masses progressing and compressing the pancreatic duct.
  • Pancreatic biopsy revealed CD4+ T-lymphocyte infiltration and HLA-DR expression on ductal and acinar cells.

Findings:

  • The clinical and pathological findings strongly suggested autoimmune-related pancreatitis.

Related Experiment Videos

  • Treatment with oral prednisolone resulted in marked improvement of pancreatic abnormalities.
  • This case highlights the association between Sjögren's syndrome and autoimmune-related pancreatic masses.

    • Implications:

    • Autoimmune pancreatitis should be considered in patients with Sjögren's syndrome presenting with pancreatic masses.
    • Understanding the immunological mechanisms is crucial for managing this condition.
    • Early diagnosis and immunosuppressive therapy can lead to favorable outcomes.