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Rapid rate transcranial magnetic stimulation--a safety study

M Jahanshahi¹, M C Ridding, P Limousin

¹Department of Clinical Neurology, National Hospital for Neurology and Neurosurgery, London, UK.

Electroencephalography and Clinical Neurophysiology

|February 4, 1998

Summary

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Repeated rapid-rate transcranial magnetic stimulation (rrTMS) showed no adverse effects in healthy subjects. This safe technique using specific parameters is valuable for studying cognitive, sensory, and motor functions.

Area of Science:

Neuroscience
Neuromodulation

Background:

Transcranial magnetic stimulation (TMS) is a non-invasive brain stimulation technique.
Rapid-rate TMS (rrTMS) offers potential for prolonged cortical disruption.

Purpose of the Study:

To assess the safety and functional effects of repeated short trains of rrTMS over the left motor cortex.
To evaluate neurological, cognitive, and motor functions following rrTMS application.

Main Methods:

Six healthy subjects received two blocks of rrTMS (50 trains of 4 stimuli at 20 Hz, 5-10% above motor threshold).
EEG, neurological, cognitive, and motor functions were assessed pre- and post-stimulation.
EMG recorded motor evoked potentials (MEPs) from arm muscles.

Main Results:

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No adverse effects were observed during or after rrTMS.
Neurological, cognitive, and motor function measures remained unchanged.
Transient increases in MEP amplitude were noted in two subjects.

Conclusions:

Repeated rrTMS, within established guidelines, is safe for healthy individuals.
rrTMS is a promising tool for investigating cognitive, sensory, and motor functions due to its ability to disrupt cortical activity.