Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

New developments in pathogenesis of systemic vasculitis

R Nowack1, L F Flores-Suárez, F J van der Woude

  • 1Fifth Medical Clinic of Nephrology and Endocrinology, Klinikum Mannheim, Faculty of Clinical Medicine, University of Heidelberg, Germany.

Current Opinion in Rheumatology
|February 4, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Carnosinase Gene-Is It Responsible for Diabetic Nephropathy?: Carnosine as a Protective Factor in Diabetic Nephropathy: Association with a Leucine Repeat of the Carnosinase Gene CNDP1. Diabetes 54: 2320-2327, 2005.

Journal of the American Society of Nephrology : JASN·2023
Same author

Sclerodermatomyositis, ocular manifestations.

Archivos de la Sociedad Espanola de Oftalmologia·2016
Same author

Giant cell arteritis and disseminated tuberculosis: presentation of two cases.

Scandinavian journal of rheumatology·2013
Same author

Seven clinical conundrums in the treatment of ANCA-associated vasculitis.

Clinical and experimental rheumatology·2013
Same author

2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides.

Arthritis and rheumatism·2012
Same author

Complementary and alternative medications consumed by patients with head and neck carcinoma: a pilot study in Germany.

Nutrition and cancer·2012
Same journal

New approaches to the management of cutaneous lupus.

Current opinion in rheumatology·2026
Same journal

"Updates in chronic nonbacterial osteomyelitis: emerging insights across the age spectrum".

Current opinion in rheumatology·2026
Same journal

Difficult-to-treat, complex-to-manage, treatment-refractory spondyloarthritis: semantics or substance?

Current opinion in rheumatology·2026
Same journal

Update on IgA nephropathy: implications for treatment in IgA vasculitis: a guide for rheumatologists.

Current opinion in rheumatology·2026
Same journal

Polyarticular juvenile idiopathic arthritis: insights from genetic studies on disease risk and pathogenesis.

Current opinion in rheumatology·2026
Same journal

Immune dysregulation in children with Down syndrome: clinical implications and emerging therapies.

Current opinion in rheumatology·2026
See all related articles

Primary systemic vasculitis causes remain unclear, but infections and environmental toxins may trigger it. Genetic predisposition plays a key role in vasculitis development.

Area of Science:

  • Immunology
  • Pathogenesis
  • Genetics

Background:

  • The etiology of primary systemic vasculitis is largely unknown.
  • Emerging evidence suggests infections and environmental toxins may precipitate these conditions.
  • Genetic factors, including hereditary alpha 1-antitrypsin deficiency and human leukocyte antigen associations, are increasingly implicated.

Purpose of the Study:

  • To review current understanding of primary systemic vasculitis pathogenesis.
  • To highlight recent advancements in identifying etiological factors.
  • To explore the interplay between genetic predisposition and environmental triggers.

Main Methods:

  • Review of recent scientific literature on vasculitis pathogenesis.
  • Analysis of data linking infections, toxins, and genetic factors to vasculitis.

Related Experiment Videos

  • Examination of cellular and molecular mechanisms involved in vasculitic inflammation.

    • Main Results:

    • Antimicrobial treatment has shown success in ameliorating systemic vasculitis.
    • New data support a role for environmental toxins and genetic predisposition.
    • Advances in identifying inflammatory mediators and cell-vascular interactions in vasculitis.

    Conclusions:

    • Primary systemic vasculitis pathogenesis is multifactorial, involving genetic susceptibility and potential environmental triggers.
    • Infections and toxins may precipitate vasculitis in genetically predisposed individuals.
    • Further research into the molecular mechanisms of vasculitic inflammation is ongoing.