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Rheumatic manifestations of hematologic disorders
J A Aviña-Zubieta1, G Galindo-Rodriguez, C Lavalle
1Departamento de Reumatologia, Hospital de Especialidades Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, Colonia La Raza, México, D.F., Mexico.
Current Opinion in Rheumatology
|February 4, 1998
Summary
Rheumatic manifestations in hematologic diseases are common, particularly joint bleeding in hemophilia. New research links arthritis and vasculitis to myelodysplastic and lymphoproliferative disorders.
Area of Science:
- Rheumatology
- Hematology
Background:
- Rheumatic manifestations frequently occur in patients with hematologic diseases.
- Joint bleeding is a significant concern in hemophilia, affecting knees, elbows, and ankles in adults, and ankles in children.
Purpose of the Study:
- To review recent literature on rheumatic manifestations in hematologic diseases.
- To highlight emerging associations and treatment outcomes.
Main Methods:
- Literature review of studies published within the past year.
- Analysis of findings related to hemophilia, myelodysplastic syndromes, lymphoproliferative disorders, beta-thalassemia, and bone marrow transplantation.
Main Results:
- 80% of hemorrhage in hemophilia occurs in joints; septic arthritis is a growing concern with HIV.
- Radioactive synoviorthesis is as effective as surgical synovectomy for hemarthrosis at lower costs.
- Associations between arthritis/vasculitis and myelodysplastic/lymphoproliferative disorders were identified.
- Increased scoliosis incidence in beta-thalassemia patients noted.
- Rheumatoid arthritis progression post-bone marrow transplantation was documented.
Conclusions:
- Hematologic disorders present diverse rheumatic manifestations requiring attention.
- Innovative treatments like radioactive synoviorthesis offer cost-effective alternatives.
- Further research is needed to understand the complex interplay between hematologic and rheumatic conditions.