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Published on: October 21, 2010
KY-62, a polyene analog of amphotericin B, for treatment of murine candidiasis
J R Graybill1, L K Najvar, A Fothergill
1University of Texas Health Science Center, San Antonio 78284, USA. graybill@uthscsa.edu
Abstract:
KY-62 is a water-soluble analog of amphotericin B. In vitro testing of five clinical isolates of Candida albicans showed KY-62 to have potency similar to that of amphotericin B. KY-62 was administered to mice infected intravenously with C. albicans. In vivo, KY-62 was effective in immunocompetent mice, with potency similar to that of amphotericin B. KY-62 was well tolerated up to 30 mg/kg of body weight per dose, an amount that would be lethal with amphotericin B. KY-62 was less effective in mice rendered neutropenic with 5-fluorouracil. The addition of flucytosine had little effect. KY-62 may have potential for clinical development.
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