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Preparation of (R)-N-methylsalsolinol via reversed-phase high-performance liquid chromatography using
Journal of Chromatography. B, Biomedical Sciences and Applications
|February 4, 1998
Abstract:
A new preparation method was devised using beta-cyclodextrin as a mobile-phase additive in a reversed-phase high-performance liquid chromatography system. Preparative separation of the biologically active (R)-enantiomer was achieved from racemic N-methylsalsolinol. Beta-cyclodextrin was removed completely in good yield by acid extraction and solid-phase extraction. By a slight modification, this method will be applicable to the isolation of various types of biologically important enantiomers.