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Related Experiment Videos

Cortical activation MR studies in brain disorders

B R Buchbinder1, G R Cosgrove

  • 1Division of Neuroradiology, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.

Magnetic Resonance Imaging Clinics of North America
|March 21, 1998
PubMed
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Functional MRI (magnetic resonance imaging) activation studies map brain functions like sensorimotor and language. This review details techniques, emphasizing BOLD-fMRI, for clinical applications in neurosurgery and neuropsychiatric disorders.

Area of Science:

  • Neuroimaging
  • Functional Magnetic Resonance Imaging (fMRI)
  • Clinical Neuroscience

Background:

  • Functional MRI activation studies are crucial for understanding brain function.
  • Various techniques exist, based on cerebral blood volume, flow, and oxygenation.
  • The Blood Oxygen Level Dependent (BOLD) technique is a primary method.

Purpose of the Study:

  • To present the principles and clinical applications of functional MRI activation studies.
  • To review the physical and physiological basis of different fMRI techniques.
  • To highlight the methodology and applications of BOLD-fMRI.

Main Methods:

  • Review of physical and physiological principles of fMRI techniques.
  • Emphasis on the methodology of Blood Oxygen Level Dependent (BOLD) fMRI.

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  • Illustration of clinical applications through case examples.

    • Main Results:

    • Functional MRI activation studies provide valuable insights into brain function.
    • BOLD-fMRI is a key technique with diverse applications.
    • Presurgical mapping and neuropsychiatric disease applications are demonstrated.

    Conclusions:

    • Functional MRI is a powerful tool for clinical neuroscience.
    • BOLD-fMRI has significant applications in presurgical planning and understanding neuropsychiatric conditions.
    • Further applications in diagnosing and managing neurological and psychiatric disorders are anticipated.