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Related Concept Videos

Intrarenal Drug Delivery in Rats: A Method to Deliver Therapeutic Drugs in Rat Kidney via Intra-arterial Injection05:10

Intrarenal Drug Delivery in Rats: A Method to Deliver Therapeutic Drugs in Rat Kidney via Intra-arterial Injection

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In this video, we demonstrate intra-renal drug administration in rats via the renal artery. This method is beneficial in improving drug targeting, drug potency, and minimizing systemic...
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We present a technique for localized administration of drugs through the trans-tympanic route into the cochlea. Drug delivery through this route would not interfere with the anti-cancer efficacy of the chemotherapeutic drugs such as...
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After puncturing the aorta through the inferior vena cava (IVC) to create an aorto-caval fistula in the mouse, solution containing a drug is infused into the IVC via the same needle, followed by incubation. This method enables more robust drug delivery to the venous endothelium compared to the external...
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The Mesenteric Lymph Duct Cannulated Rat Model: Application to the Assessment of Intestinal Lymphatic Drug Transport13:17

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Here we describe a technique to cannulate the mesenteric lymph duct in rats which enables quantification of lipid and drug transport via the lymphatic system following intestinal delivery. The technique can be adapted to assess mesenteric lymph concentrations and/or transport of fluid, immune cells, peptides, proteins and lipophilic...
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Drug Delivery: Overview01:16

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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
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Drug Delivery: Enteral Route01:18

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The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
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Related Experiment Video

Updated: Jan 20, 2026

Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity
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Drug delivery to the lymphatic system

C J Porter1

  • 1Department of Pharmaceutics, Victorian College of Pharmacy, Monash, Australia.

Critical Reviews in Therapeutic Drug Carrier Systems
|January 1, 1997
PubMed
Summary

This review explores drug delivery to the lymphatic system for targeted therapies. It examines methods for enhancing drug transport via lymphatic pathways for improved systemic circulation.

Area of Science:

  • Pharmacology
  • Biomedical Engineering
  • Drug Delivery Systems

Background:

  • The lymphatic system's unique structure and function are of significant interest for drug delivery applications.
  • Targeting the lymphatics offers potential for both localized treatment and systemic drug distribution.

Purpose of the Study:

  • To review current strategies for drug delivery to the lymphatic system.
  • To discuss methods for achieving site-specific delivery to lymph and lymphoid tissues.
  • To examine lymphatic transport mechanisms for systemic drug circulation.

Main Methods:

  • Discussion of drug access routes, including parenteral and enteral administration.
  • Examination of macromolecular and lipophilic prodrug strategies.
  • Analysis of microparticulate systems like microspheres, liposomes, and colloidal carbon.

More Related Videos

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Intraluminal Drug Delivery to the Mouse Arteriovenous Fistula Endothelium

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The Mesenteric Lymph Duct Cannulated Rat Model: Application to the Assessment of Intestinal Lymphatic Drug Transport
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Related Experiment Videos

Last Updated: Jan 20, 2026

Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity
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Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity

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Intraluminal Drug Delivery to the Mouse Arteriovenous Fistula Endothelium
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Intraluminal Drug Delivery to the Mouse Arteriovenous Fistula Endothelium

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The Mesenteric Lymph Duct Cannulated Rat Model: Application to the Assessment of Intestinal Lymphatic Drug Transport
13:17

The Mesenteric Lymph Duct Cannulated Rat Model: Application to the Assessment of Intestinal Lymphatic Drug Transport

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Main Results:

  • Drug access to lymphatics can be achieved from vasculature, interstitium, or the gastrointestinal tract.
  • Prodrug approaches and microparticulate systems show promise for lymphatic targeting.
  • Understanding lymphatic transport is key for optimizing drug delivery efficacy.

Conclusions:

  • Effective drug delivery to the lymphatic system requires tailored strategies.
  • Various approaches, including prodrugs and nanoparticles, can enhance lymphatic uptake.
  • Further research into lymphatic transport mechanisms can optimize drug targeting and systemic delivery.