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Developmental changes in plasma membrane fluidity in chick embryo heart

H Kutchai, Y Barenholz, T F Ross

    Biochimica Et Biophysica Acta
    |June 4, 1976
    PubMed
    Summary
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    As chick embryos develop, their heart cell membranes become more fluid, impacting nutrient and waste transport. This study links developmental changes in membrane fluidity to altered transport rates.

    Area of Science:

    • Biochemistry
    • Developmental Biology
    • Cell Physiology

    Background:

    • Nutrient and waste transport in chick embryo hearts changes during development.
    • Plasma membrane fluidity may influence these transport activities.

    Purpose of the Study:

    • To investigate the relationship between plasma membrane fluidity and developmental changes in transport activity in the chick embryo heart.
    • To quantify changes in membrane viscosity during embryonic and post-hatch development.

    Main Methods:

    • Developed techniques for subcellular fractionation of chick embryo and adult chicken hearts.
    • Utilized 1,6-diphenylhexatriene fluorescence depolarization to measure plasma membrane fluidity.
    • Analyzed membrane-enriched fractions from hearts at various developmental stages.

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    Main Results:

    • A significant decrease in plasma membrane viscosity was observed during development.
    • A 20% decrease in viscosity occurred between 5-6 and 10 days of embryonic life.
    • A further 55% decrease in viscosity was noted between 20 days of development and adulthood.

    Conclusions:

    • Plasma membrane fluidity increases during chick embryo heart development.
    • Changes in membrane fluidity likely contribute to altered transport rates of sugars, amino acids, and urea.
    • Other factors are also involved in the developmental regulation of membrane transport.