Receptor protein tyrosine phosphatases: involvement in cell-cell interaction and signaling

Receptor protein tyrosine phosphatases (RPTPs) represent a relatively new family of cell-surface receptors consisting of a variable, putative ligand-binding ectodomain followed by a single transmembrane segment and one or two intracellular catalytic domains. The RPTPs are thought to transduce extracellular signals by dephosphorylating tyrosine-phosphorylated intracellular substrates. As such, they are the enzymatic counterparts of the well studied receptor tyrosine kinases. However, little is known about the signaling mechanisms and biological functions of the RPTPs. Recent studies show that the extracellular domain of certain RPTPs can mediate either homophilic or heterophilic interactions and suggest a role in cadherin-mediated cell-cell adhesion, possibly via an action on catenins. This review will focus on the role of RPTPs in cell-cell interaction and the possible biological implications.