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[Calcifying granulomatous peritendinitis after local dexamethasone treatment]
J Friemann1, G Mogilevski, D Höhr
1Abteilung für Umweltpathologie, Heinrich-Heine-Universität Düsseldorf.
Der Pathologe
|February 6, 1998
Summary
Cortisone injections with soybean oil for epicondylitis can cause fat necrosis. Histological examination revealed calcifying collagen fiber necrosis, potentially induced by the soybean oil carrier.
Area of Science:
- Histopathology
- Dermatology
- Rheumatology
Background:
- Epicondylitis humeri radialis (tennis elbow) is often treated with corticosteroid injections.
- Soybean oil is sometimes used as a carrier agent in pharmaceutical preparations.
Observation:
- A 43-year-old male patient received two cortisone injections containing soybean oil for epicondylitis.
- Post-injection, surgically extracted necrotized fat tissue was submitted for histological analysis.
Findings:
- Histological examination revealed calcifying collagen fiber necrosis.
- A granulomatous reaction was observed, actively clearing the necrotic tissue.
- Resorption of necrotic collagen fibers by granulation tissue was evident.
Implications:
- Soybean oil, used as a drug carrier, may induce calcifying collagen fiber necrosis.
- This finding highlights a potential adverse reaction to corticosteroid injections with lipid-based carriers.
- Understanding such reactions is crucial for optimizing treatment strategies and patient safety.