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Extracellular annexin II

D A Siever1, H P Erickson

  • 1Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA.

The International Journal of Biochemistry & Cell Biology
|February 6, 1998
PubMed
Summary
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Extracellular annexin II, a calcium-dependent protein, functions as a cell-surface receptor. Its roles in fibrinolysis, cell adhesion, and signaling suggest therapeutic potential.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Background:

  • Annexin II is a calcium-dependent, phospholipid-binding protein.
  • Initially identified with intracellular functions, extracellular annexin II is now recognized.
  • Its secretion mechanism remains unknown, but it exists in soluble and membrane-bound forms.

Purpose of the Study:

  • To review the emerging roles of extracellular annexin II.
  • To highlight its function as a cell-surface receptor.
  • To explore therapeutic possibilities targeting extracellular annexin II.

Main Methods:

  • Literature review and synthesis of existing research on annexin II.
  • Analysis of studies identifying extracellular annexin II in various tissues.

Related Experiment Videos

  • Examination of annexin II's interactions with polypeptide ligands.

    • Main Results:

    • Extracellular annexin II acts as a receptor for multiple polypeptide ligands.
    • It is implicated in critical biological processes including fibrinolysis, cell adhesion, and signaling.
    • Cell-surface annexin II plays a role in virus infection.

    Conclusions:

    • Extracellular annexin II has diverse biological functions beyond its intracellular roles.
    • Its receptor function and involvement in key processes present therapeutic opportunities.
    • Further research is needed to fully understand annexin II's extracellular biology and therapeutic applications.