Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cartilage-derived morphogenetic protein-1

F P Luyten1

  • 1Craniofacial and Skeletal Diseases Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892-1188, USA.

The International Journal of Biochemistry & Cell Biology
|February 6, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The effects of a sleeve knee brace during stair negotiation in patients with symptomatic patellofemoral osteoarthritis.

Clinical biomechanics (Bristol, Avon)·2023
Same author

Bio-optimized Curcuma longa extract is efficient on knee osteoarthritis pain: a double-blind multicenter randomized placebo controlled three-arm study.

Arthritis research & therapy·2019
Same author

Advancing osteochondral tissue engineering: bone morphogenetic protein, transforming growth factor, and fibroblast growth factor signaling drive ordered differentiation of periosteal cells resulting in stable cartilage and bone formation in vivo.

Stem cell research & therapy·2018
Same author

Toward classification criteria for early osteoarthritis of the knee.

Seminars in arthritis and rheumatism·2017
Same author

Pharmacological treatment of osteoporosis in the oldest old.

Clinical interventions in aging·2017
Same author

Definition of a Critical Size Osteochondral Knee Defect and its Negative Effect on the Surrounding Articular Cartilage in the Rat.

Osteoarthritis and cartilage·2017
Same journal

Corrigendum to "Sodium butyrate down-regulation of indoleamine 2, 3-dioxygenase at the transcriptional and post-transcriptional levels" [Int. J. Biochem. Cell Biol. 42 (2010) 1840-1846].

The international journal of biochemistry & cell biology·2026
Same journal

Whole-brain spatial metabolomics reveals metabolic gradient shifts in a murine glioma model following boron neutron capture therapy (130 characters).

The international journal of biochemistry & cell biology·2026
Same journal

LCN2 modulates Th17/Treg balance in vitro and is associated with an adaptive response to intestinal ischemia-reperfusion injury under Hmox1-deficient conditions.

The international journal of biochemistry & cell biology·2026
Same journal

Chloroquine modulates the redox-sensitive signalling via inhibiting the AMPK-ULK1 under LPS induced state in murine splenic macrophages.

The international journal of biochemistry & cell biology·2026
Same journal

The vicious cycle of hyperglycemia and oxidative stress: Novel mechanistic insights into a pathogenic alliance.

The international journal of biochemistry & cell biology·2026
Same journal

Fibroblast growth factors (FGF) in the pathogenesis and treatment of inflammatory bowel diseases (IBD): An overview.

The international journal of biochemistry & cell biology·2026
See all related articles

A newly identified protein, Cartilage-derived morphogenetic protein-1 (Cdmp1), is crucial for skeletal and joint development. This protein shows potential as a therapeutic agent for regenerating bone and cartilage tissues.

Area of Science:

  • Molecular Biology
  • Developmental Biology
  • Biochemistry

Background:

  • A novel morphogenic secreted protein, Cartilage-derived morphogenetic protein-1 (Cdmp1), and its mouse homologue, growth/differentiation factor 5 (Gdf5), were identified.
  • Cdmp1/Gdf5 belongs to the TGF-beta superfamily, involved in signaling pathways.
  • Its expression is primarily observed in the developing appendicular skeleton.

Purpose of the Study:

  • To investigate the role of Cdmp1/Gdf5 in skeletal development and joint morphogenesis.
  • To explore the potential of Cdmp1/Gdf5 as a therapeutic agent for skeletal tissue regeneration.

Main Methods:

  • Degenerate PCR screening for bone morphogenetic protein-like genes.
  • Analysis of temporal and spatial expression patterns.

Related Experiment Videos

  • Genetic studies utilizing null mutations in mice and human studies.
  • In vitro and in vivo studies using recombinantly expressed Cdmp1/Gdf5 protein.

    • Main Results:

    • Null mutations in the Cdmp1/Gdf5 gene lead to skeletal abnormalities, including short limbs (brachypodism) in mice and acromesomelic chondrodysplasia in humans.
    • Recombinant Cdmp1/Gdf5 protein demonstrated the ability to initiate and promote chondrogenesis.
    • The protein also exhibited a limited capacity to induce osteogenesis in vitro and in vivo.

    Conclusions:

    • Cdmp1/Gdf5 plays a significant role in skeletal development and joint formation.
    • The findings suggest Cdmp1/Gdf5 is a promising candidate for therapeutic applications in skeletal tissue regeneration.