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Updated: Aug 12, 2026
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A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
[Radiotherapy of localized prostatic carcinoma]
E Gez1, Y Netzer-Horowitz, E Waiman
1Northern Israel Oncology Center, Rambam Medical Center, Haifa.
Harefuah
|February 6, 1998
Summary
External beam radiotherapy is effective for localized prostate cancer. Survival rates depend on cancer stage and tumor differentiation, highlighting these as key prognostic factors.
Area of Science:
- Oncology
- Radiation Oncology
Context:
- Localized prostate cancer presents a significant clinical challenge.
- Definitive radiotherapy is a primary treatment modality for localized prostate cancer.
Purpose:
- To evaluate the long-term efficacy of external beam radiotherapy in patients with localized prostate cancer.
- To identify prognostic factors influencing survival outcomes in treated patients.
Summary:
- A study of 112 patients with localized prostate cancer (stages A2-C) treated with definitive radiotherapy between 1982-1988.
- Radiation encompassed the prostate, seminal vesicles, and pelvic lymph nodes.
- Ten-year actuarial survival was 51% overall, with variations based on stage (A2: 87%, B: 50%, C: 36%) and tumor differentiation (well: 67%, moderate: 50%, poor: 32%). Local tumor control also impacted survival (55% vs. 36%).
Impact:
- External beam irradiation demonstrates effectiveness in treating localized prostate cancer.
- Prostate cancer stage and tumor grade are significant prognostic indicators for patient survival.
- Findings support radiotherapy as a viable treatment option and underscore the importance of staging and grading in predicting outcomes.
