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Hydrocephalus and craniosynostosis

G Cinalli1, C Sainte-Rose, E M Kollar

  • 1Department of Pediatric Neurosurgery, Hôpital Necker-Enfants Malades, Université René Descartes, Paris, France.

Journal of Neurosurgery
|February 6, 1998
PubMed
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Abnormal cerebrospinal fluid (CSF) hydrodynamics are linked to craniosynostosis, particularly in syndromic cases. Hydrocephalus is common in syndromic craniosynostosis, especially with kleeblattschädel and Crouzon

Area of Science:

  • Neurosurgery
  • Pediatric Neurosurgery
  • Craniofacial Surgery

Background:

  • Craniosynostosis involves the premature fusion of cranial sutures, impacting skull development.
  • Cerebrospinal fluid (CSF) hydrodynamics may play a role in the pathophysiology of craniosynostosis.
  • Understanding this relationship is crucial for effective management and surgical planning.

Purpose of the Study:

  • To investigate the interrelationship between abnormal cerebrospinal fluid (CSF) hydrodynamics and craniosynostosis.
  • To determine the prevalence and types of CSF hydrodynamic disturbances in patients with craniosynostosis.
  • To compare the incidence of abnormal CSF hydrodynamics between syndromic and nonsyndromic craniosynostosis.

Main Methods:

  • Retrospective study of 1727 patients with craniosynostosis.

Related Experiment Videos

  • Exclusion of specific cases like occipital plagiocephaly and shunt-induced craniosynostosis.
  • Review of clinical and radiographic data, with a 5-year follow-up for surgically treated patients.

    • Main Results:

    • Abnormal intracranial CSF hydrodynamics were identified in 8.1% of patients.
    • Hydrocephalus was significantly more frequent in syndromic craniosynostosis (12.1%) compared to isolated cases (0.3%).
    • Kleeblattschädel and Crouzon's syndrome showed a high incidence of hydrocephalus; Apert's syndrome often presented with nonprogressive ventriculomegaly.

    Conclusions:

    • Abnormal CSF hydrodynamics are associated with craniosynostosis, especially syndromic forms.
    • Venous sinus obstruction and tonsillar herniation are frequently observed in syndromic cases, potentially contributing to hydrocephalus.
    • These findings highlight the importance of assessing CSF dynamics in craniosynostosis management.