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Diversity among multidrug-resistant enterococci

B E Murray1

  • 1University of Texas Houston-Medical School, Houston 77030, USA.

Emerging Infectious Diseases
|March 21, 1998
PubMed
Summary
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Enterococci cause infections and are difficult to treat due to widespread antimicrobial resistance. Their ability to acquire and spread resistance genes makes them a persistent public health challenge.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Enterococci are significant pathogens in both community- and hospital-acquired infections.
  • Despite not typically causing severe systemic inflammation, enterococci exhibit extensive resistance to numerous antimicrobial agents.
  • This resistance profile complicates treatment strategies for enterococcal infections.

Purpose of the Study:

  • To highlight the challenges posed by enterococcal antimicrobial resistance.
  • To explore the mechanisms underlying enterococcal resistance acquisition and spread.
  • To underscore the ongoing threat of multidrug-resistant enterococci.

Main Methods:

  • Literature review and synthesis of existing data on enterococcal resistance.

Related Experiment Videos

  • Analysis of genetic mechanisms of resistance transfer (conjugation, transposons, plasmids).
  • Evaluation of enterococcal hardiness and environmental survival.

    • Main Results:

    • Enterococci demonstrate resistance to cell-wall active agents, aminoglycosides, penicillins, ampicillin, and vancomycin.
    • Co-resistance to multiple drugs is common, particularly with vancomycin resistance.
    • Enterococci readily acquire resistance genes via conjugation, facilitated by plasmids and transposons.

    Conclusions:

    • Enterococcal antimicrobial resistance, driven by gene acquisition and transfer, presents a significant therapeutic challenge.
    • Bacterial hardiness contributes to the environmental persistence and spread of multidrug-resistant enterococcal clones.
    • Enterococci will continue to be a formidable challenge in clinical settings due to their resistance.