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Pleuromutilins. Fermentation, structure and biosynthesis

F Knauseder, E Brandl

The Journal of Antibiotics

|February 1, 1976

Abstract:

Derivatives of pleuromutilin, formed during the fermentation of pleuromutilin, were isolated and their structure determined. 14-Acetyl-mutilin and mutilin as well as different unsaturated fatty acid esters of pleuromutilin were identified. The proportion of each derivative formed depends to a considerable degree on the conditions of the fermentation process. The possible biosynthetic pathways are shown.

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