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Travel to sunny countries is associated with changes in immunological parameters
1Research Institute Gastein-Tauernregion, Badgastein, Germany.
Photodermatology, Photoimmunology & Photomedicine
|August 1, 1997
Summary
Sunshine vacations without adaptation can alter immune function. Key changes observed include decreased CD4/8 ratio and IgG, with increased sIL-2R, sCD14, IgA, and C3 levels, indicating significant immune system shifts.
Area of Science:
- Immunology
- Dermatology
- Public Health
Background:
- Laboratory studies indicate ultraviolet (UV) radiation alters immunological parameters.
- The impact of natural UV exposure, such as during vacations, on immune function without prior adaptation is less understood.
Purpose of the Study:
- To investigate immune system changes in volunteers after a sunny vacation without prior UV adaptation.
- To assess alterations in white blood cells, lymphocyte subpopulations, and serum markers post-vacation.
Main Methods:
- 32 volunteers had immunological parameters measured before and after a winter vacation in a sunny country.
- Parameters included white blood cells, lymphocyte subpopulations, soluble interleukin-2 receptor (sIL2-R), soluble CD14 (sCD14), immunoglobulins (IgG, IgA), and complement factor C3.
- UVB exposure was confirmed via questionnaires, dosimetry, and increased 25-hydroxyvitamin D levels.
Main Results:
- Significant decrease in the CD4/8 ratio and serum IgG concentration post-vacation.
- Significant increase in serum concentrations of sIL2-R, sCD14, IgA, and C3.
- Increased 25-hydroxyvitamin D confirmed substantial UVB exposure.
Conclusions:
- Vacationing in sunny regions without prior UV adaptation can lead to significant immune system alterations.
- Observed changes suggest a notable impact of natural UVB exposure on immune markers.