Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Relationship between rat brain and cisternal CSF tryptophan concentrations

S N Young, P Etienne, T L Sourkes

    Journal of Neurology, Neurosurgery, and Psychiatry
    |March 1, 1976
    PubMed
    Summary

    Measuring cerebrospinal fluid (CSF) tryptophan in humans may help study brain tryptophan levels. However, due to a weak correlation, CSF tryptophan is more useful for group studies than individuals.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Review: Closing nutrient cycles for animal production - Current and future agroecological and socio-economic issues.

    Animal : an international journal of animal bioscience·2021
    Same author

    On the "Flu"-A Theory.

    The Dental register·2021
    Same author

    A Citrus Based Sensory Functional Food Ingredient Induces Antidepressant-like Effects: Possible Involvement of an Interplay between the Olfactory and the Serotonergic Systems.

    Neuroscience·2020
    Same author

    Acute meningoencephalitis in a patient with COVID-19.

    Revue neurologique·2020
    Same author

    Streamlined guidelines for antibiotic therapies are required for greater efficacy.

    Medecine et maladies infectieuses·2019
    Same author

    Pharmacokinetic and antimicrobial activity of a new carvacrol-based product against a human pathogen, Campylobacter jejuni.

    Journal of applied microbiology·2018

    Area of Science:

    • Neuroscience
    • Biochemistry

    Background:

    • Tryptophan is a crucial amino acid precursor to serotonin, influencing mood and behavior.
    • Accurate measurement of brain tryptophan is vital for understanding neurological and psychiatric conditions.

    Purpose of the Study:

    • To investigate the correlation between tryptophan concentrations in rat brain and cerebrospinal fluid (CSF).
    • To assess the utility of CSF tryptophan as a biomarker for brain tryptophan levels in humans.

    Main Methods:

    • Tryptophan levels were quantified in the cisternal CSF and brains of rats.
    • The study examined the effects of starvation, glucose feeding, and lithium treatment on tryptophan concentrations.
    • Diurnal variations in tryptophan levels were also analyzed.

    Main Results:

    • A significant but weak correlation was observed between brain and CSF tryptophan concentrations in untreated rats.
    • Factors altering brain tryptophan, including starvation, glucose, and lithium, similarly affected CSF tryptophan.
    • Parallel diurnal changes were noted in both brain and CSF tryptophan.

    Conclusions:

    • CSF tryptophan levels in rats reflect changes in brain tryptophan concentrations.
    • Measurement of lumbar CSF tryptophan in humans may serve as a valuable tool for studying brain tryptophan.
    • Due to the imperfect correlation, CSF tryptophan measurements are more meaningful for group analyses than for individual assessments.

    Related Experiment Videos