Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Thrombolytic therapy in ischemic infarct]

V Willig1, T Steiner, W Hacke

  • 1Neurologische Universitätsklinik Heidelberg, Bundesrepublik Deutschland.

Wiener Klinische Wochenschrift
|February 7, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Palliative neurology].

Die Anaesthesiologie·2024
Same author

[Palliative neurology].

Der Nervenarzt·2024
Same author

Quantitative analysis of the impact of infectious disease physicians on patients in the emergency department fast-track parenteral antibiotics program.

BMC infectious diseases·2024
Same author

Performance of commercial growing-finishing pigs fed supplemental isoquinoline alkaloids: a statistical process control analysis.

Porcine health management·2023
Same author

Identification of risk factors for postoperative delirium in patients following intraoral reconstruction with microvascular free flaps: a matched-pair analysis.

International journal of oral and maxillofacial surgery·2023
Same author

Perfusion of microvascular free flaps in head and neck reconstruction after prior neck dissection and irradiation.

International journal of oral and maxillofacial surgery·2022

Thrombolytic therapy using recombinant tissue plasminogen activator (rt-PA) is safe and effective for acute ischemic stroke patients within 6 hours of symptom onset. Careful patient selection is crucial for optimal outcomes and minimizing hemorrhage risks.

Area of Science:

  • Neurology
  • Cardiovascular Medicine

Background:

  • Thrombolytic therapy is a key treatment for acute ischemic stroke.
  • Various fibrinolytic agents like urokinase, streptokinase, and rt-PA have been evaluated.
  • Previous studies focused on safety, efficacy, dosage, and economic parameters.

Purpose of the Study:

  • To evaluate the safety and efficacy of thrombolytic therapy in acute ischemic stroke.
  • To assess outcomes in patients treated with rt-PA in carotid and basilar artery territories.
  • To analyze clinical and economic outcomes based on treatment timing and imaging findings.

Main Methods:

  • Review of two large multicenter placebo-controlled intravenous rt-PA studies.
  • Analysis of European Cooperative Acute Stroke Study and NIH Stroke Scale rt-PA Stroke Study data.

Related Experiment Videos

  • Inclusion of patients treated within 6 hours with no signs of extended early infarction on CT scans.

    • Main Results:

    • Intravenous rt-PA improves clinical and economic outcomes for acute carotid territory strokes within 6 hours.
    • Thrombolysis is effective for strokes with NIH Stroke Scale-measurable deficits within 6 hours.
    • Intracranial hemorrhages are more frequent but often limited to infarcted tissue without clinical deterioration.
    • Intra-arterial thrombolysis for vertebrobasilar strokes within 12 hours shows improved survival and neurological recovery.

    Conclusions:

    • Thrombolytic therapy, particularly rt-PA, is safe and effective in selected acute ischemic stroke patients.
    • Timely treatment and appropriate patient selection based on clinical and imaging criteria are essential.
    • Further research is needed to refine patient identification and optimize treatment protocols for diverse stroke types.