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[Neurological manifestations on collagenoses]

V Ambăruş1, A Cosovanu, G Ungureanu

  • 1Facultateta de Medicină, Universitatea de Medicină şi Farmacie Gr. T. Popa, Iaşi.

Revista Medico-Chirurgicala a Societatii De Medici Si Naturalisti Din Iasi
|January 1, 1996
PubMed
Summary

Collagen diseases, characterized by autoimmune processes and vascular damage, frequently cause neurological dysfunction. Peripheral nervous system involvement is more common and responsive to corticosteroid therapy than central nervous system effects.

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Area of Science:

  • Rheumatology
  • Neurology
  • Pathology

Context:

  • Collagen diseases share autoimmune pathogenesis and chronic, progressive vascular ischemic lesions.
  • These vascular lesions lead to plurivisceral involvement and secondary pathologies.
  • Neurological dysfunctions are a significant complication in collagen diseases.

Purpose:

  • To analyze the prevalence and characteristics of neurological dysfunctions in patients with collagen diseases.
  • To investigate the onset and progression of neurological manifestations.
  • To evaluate the efficacy of corticosteroid therapy on neurological involvement.

Summary:

  • Neurological dysfunctions were observed in approximately 50% of collagen disease cases over a 25-year period.
  • Manifestations varied, with inaugural neurological symptoms occurring in 10-46.4% of specific conditions like Systemic Lupus Erythematosus and Polyarteritis Nodosa.

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  • Peripheral nervous system involvement, primarily polyneuritis, was more prevalent than central nervous system involvement, which was rarer and often fatal.

    • Impact:

    • Highlights the significant impact of neurological complications in collagen diseases.
    • Suggests differential therapeutic responses, with corticosteroids being more effective for peripheral than central nervous system involvement.
    • Underscores the importance of monitoring for and managing neurological deficits in collagenosis management.