[The clinico-epidemiological premises for antioxidant prevention and treatment in chronic myocardial infarct]
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D Azoicăi1, F Mitu, A Iacobovici
1Disciplina de Epidemiologie, Universitatea de Medicină şi Farmacie Gr. T. Popa, Iaşi.
Insights
Chronic myocardial infarction (IMC) management requires assessing cardiovascular risk factors. This study highlights the need for preventive strategies and complex therapies, including antioxidant treatment, to manage oxidative stress and improve patient outcomes.
Area of Science:
- Cardiology
- Epidemiology
- Biochemistry
Context:
- Chronic myocardial infarction (IMC) presents complex epidemiological challenges for global cardiovascular risk assessment.
- A retrospective study evaluated risk factors in 38 hospitalized patients, identifying constitutional and behavioral factors.
- Risk quantification using the Euro 194 graph revealed 50% of IMC cases had a 10-20% global risk.
Purpose:
- To evaluate epidemiological risk factors and biochemical markers in chronic myocardial infarction (IMC) patients.
- To correlate lipid peroxidation products (malondialdehyde) with clinical status and comorbidities.
- To determine the necessity of complex therapeutic interventions, including antioxidant treatment.
Summary:
- Epidemiological assessment of 38 hospitalized chronic myocardial infarction (IMC) patients identified significant constitutional and behavioral risk factors.
- Biochemical analysis classified dyslipidemic patients (ARCOL classes D, E, B) and measured malondialdehyde (MAD) as a marker of lipid peroxidation.
- Findings confirmed the need for comprehensive therapy, incorporating antioxidant treatment to combat oxidative stress.
Impact:
- Identified key risk factors and dyslipidemia patterns in chronic myocardial infarction (IMC) patients.
- Validated the role of malondialdehyde (MAD) as an indicator of oxidative stress and disease progression.
- Emphasized the importance of integrated therapeutic approaches, including antioxidants, for managing IMC and its associated risks.
Abstract:
The improvement of therapeutic and recoverable proceeding to chronic myocardial infarction (IMC) imposes a complex epidemiological estimation of the global cardiovascular risk, of their clinical and biological status. The retrospective evaluation of the risk factors (RF) by epidemiological methods, in 38 hospitalized prevalence of both constitutional and behavioral factors, and the quantification of the risk state, according to graph Euro 194, has pointed on the fact that 50% of IMC cases have presented a global risk of 10-20%. That justified the application of a preventive conduct in order to continually neutralize the associates FR. The biochemical determinations have allowed to frame the dyslipidemic patients, according to the ARCOL classification in the classes D (29.2%), E (25.0%) and B (20.8%) with direct implication in the adopted therapy. The colorimetric dozing with thyo-barbituric acid of the malonly dialdehyde (MAD) each is a product of the lipidic peroxidation, as well as the interpreting or correlation of the registered values with an evolutive clinic stage, and with the existence of some existing diseases (diabetes, chronic hepatitis etc.) along with signification of other dismethabolical parameters (cholesterol, triglycerides, LDLc, apoB) have confirmed the necessity of a complex therapy, including an antioxidative treatment, having the role to directly inhibit or exclude the free radicals resulted after the oxidative stress of the infarct.
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