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[Fibrinolysis during pregnancy. The pre- and postpartal changes]
A Bădărău1, M Artino, R Cârmaciu
1Catedra de Fiziologie Nicolae C. Paulescu, UMF Carol Davila, Bucureşti.
Summary
Plasma fibrinolytic activity (PFA) increases during labor, as measured by euglobulin lysis time (ELT). This heightened PFA was observed only during labor, not in the seventh month of pregnancy or 48 hours postpartum.
Area of Science:
- Obstetrics and Gynecology
- Hematology
- Physiology
Background:
- Previous research indicates elevated plasma fibrinolytic activity (PFA) in women during labor.
- Literature also supports increased PFA in women during childbirth.
Purpose of the Study:
- To investigate plasma fibrinolytic activity (PFA) during pregnancy and postpartum.
- To specifically examine changes in euglobulin lysis time (ELT) in women throughout gestation and after delivery.
Main Methods:
- Studied 25 healthy pregnant women aged 18-30 years.
- Measured euglobulin lysis time (ELT) in the seventh month of pregnancy, during labor, and 48 hours postpartum.
- Collected blood samples via venous puncture from the antecubital vein.
Main Results:
- Plasma fibrinolytic activity (PFA) was significantly increased only during labor, indicated by a shortened euglobulin lysis time (ELT).
- No significant changes in ELT were observed in the seventh month of pregnancy.
- Euglobulin lysis time (ELT) values returned to baseline levels by 48 hours after delivery.
Conclusions:
- Plasma fibrinolytic activity (PFA) demonstrates a distinct increase specifically during the labor process.
- The observed changes in PFA are transient and labor-specific, returning to normal postpartum.
- Euglobulin lysis time (ELT) serves as a reliable indicator of PFA fluctuations during pregnancy and postpartum.