Histopathological and enzymological liver alterations in rat liver in the napthol intoxication

The study was performed on Wistar adult rats divided in 4 experimental and 2 control groups. In the 4 experimental groups, we used the oral naphtol administration in two doses: 15 mg/kg body-weight and 1.5 mg/kg body-weight. The rats were sacrificed 3 months, respectively 10 months later. Some liver parenchyma dystrophic lesions were noticed. In the subacute test group and using high drug doses the lesions were more severe, especially in the female rats. In the chronic test groups, the lesion area was decreased and in the female rats the liver showed normal histological patterns; in this test groups we also noticed a marked hepatocyte regenerative tendency. Histoenzymatically, a decrease of SDH and ATP-ase activity was recorded. The marked decrease of the hepatocyte glycogen content correspond to an increase of the G-6-P activity.