Pharmacological properties of bis-beta-hydroxypropylmalonic acid dilactone derivatives

Acute toxicity and the action on CNS (employing behavioural tests) of bis-beta-hydroxypropylmalonic acid dilactone (D1) and its four derivatives (D2--D5) were investigated (Table 1) in mice and rats. The studied compounds showed low toxicity and were sometimes active just from high doses. D1 can be regarded as a sedative--hypnotic compound. In animals, the substituted dilactones induced the symptoms similar to those of tranquilizers.