Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

AIDS-associated intraocular lymphoma causing primary retinal vasculitis

L D Ormerod1, J E Puklin

  • 1Department of Ophthalmology, University of South Florida, College of Medicine, Tampa, USA.

Ocular Immunology and Inflammation
|February 10, 1998
PubMed
Summary

Ocular-central nervous system (CNS) lymphoma in acquired immunodeficiency syndrome (AIDS) patients can present as unexplained inflammation. Early diagnosis via vitreous biopsy is crucial for this aggressive B-cell neoplasm.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Syphilitic posterior uveitis: correlative findings and significance.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2001
Same author

Race, iris color, and age-related macular degeneration.

Transactions of the American Ophthalmological Society·2001
Same author

Acute disseminated histoplasmosis with multifocal choroiditis in a child.

The Pediatric infectious disease journal·2000
Same author

Posterior uveitis in patients with positive serology for syphilis.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2000
Same author

Ocular manifestations of cat-scratch disease.

Current opinion in ophthalmology·1999
Same author

Mechanisms of retinal arterial occlusive disease in African American and Caucasian patients.

Stroke·1999

Area of Science:

  • Ophthalmology
  • Neurology
  • Oncology

Background:

  • Increasing association between ocular-central nervous system (CNS) lymphoma and acquired immunodeficiency syndrome (AIDS).
  • Disease typically affects a younger demographic within the AIDS population.
  • Etiology of these B-cell neoplasms remains undetermined.

Observation:

  • A 26-year-old AIDS patient presented with localized retinal vasculitis and vitritis.
  • Antiviral therapy failed, prompting diagnostic vitrectomy and biopsies.
  • Cerebrospinal fluid (CSF) analysis, head MRI, and brain biopsy were conducted.

Findings:

  • Vitreous cytology confirmed ocular non-Hodgkin lymphoma.
  • Retinal biopsy revealed perivascular inflammation, not neoplastic infiltration.

Related Experiment Videos

  • MRI identified multicentric brain lesions; brain biopsy confirmed B-cell lymphoma.
  • Patient succumbed to the disease within two months despite treatment.

    • Implications:

    • Localized retinal vasculitis and vitritis may indicate early vitreous involvement in ocular-CNS lymphoma.
    • Coarse perivascular sheathing is a characteristic finding.
    • Consider ocular-CNS lymphoma in AIDS patients with unexplained posterior segment inflammation or subretinal masses.