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Cochlear histopathologic analysis in diabetic rats
B Nageris1, T Hadar, M Feinmesser
1Department of Otolaryngology-Head and Neck Surgery, Rabin Medical Center, Petah Tiqva, Israel.
Hypothesis:
This study aimed to show whether sensorineural hearing loss in diabetes mellitus is secondary to changes in the organ of Corti and stria vascularis.
Background:
The high rate of sensorineural hearing loss in diabetes mellitus has led to much speculation as to whether there is an association between the two.
Methods:
A well-established diabetic animal model was used to examine the inner ear histopathologically.
Results:
No statistical difference in the inner and outer hair cells or in the stria vascularis was shown between the genetic-diabetic rats and control subjects.
Conclusions:
If there is hearing loss with diabetes, its pathogenesis does not involve damage to the hair cells or stria vascularis.